Study finds six new gene mutations linked to obesity

WASHINGTON (Reuters) - Researchers have identified six new gene mutations linked to obesity and said on Sunday they point to ways the brain and nervous system control eating and metabolism.

"Today's findings are a major step forward in understanding how the human body regulates weight," Dr. Alan Guttmacher, Acting director of the National Human Genome Research Institute, said in a statement.

"This study essentially doubles in one fell swoop the number of known and replicated genetic factors contributing to obesity as a public health problem," added Dr. Kari Stefansson, Chief Executive Officer of deCODE Genetics of Iceland and one of the researchers.

The international team analyzed 300,000 one-letter mutations in the genetic code known as single nucleotide polymorohisms or SNPs in more than 30,000 people from Iceland, the Netherlands and the United States.

They cross-checked their findings in 40,000 people from Denmark and the United states.

They found variations in six genes -- TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 -- were strongly associated with a height-to-weight ratio known as body mass index or BMI.

"Today's findings are a major step forward in understanding how the human body regulates weight," said Guttmacher, whose institute, one of the National Institutes of Health, helped fund and conduct the study.

"One of the most notable aspects of these discoveries is that most of these new risk factors are near genes that regulate processes in the brain," added Stefansson, whose company hopes to sell genetic tests based on such discoveries.

"This suggests that as we work to develop better means of combating obesity, including using these discoveries as the first step in developing new drugs, we need to focus on the regulation of appetite at least as much as on the metabolic factors of how the body uses and stores energy," Stefansson said.

"These new variants may point to valuable new drug targets," he added.

Nearly a third of U.S. adults are considered obese with a BMI of 30 or more. Obesity is associated with more than 100,000 deaths each year in the U.S. population and trends are similar in many other countries.

"We know that environmental factors, such as diet, play a role in obesity, but this research further provides evidence that genetic variation plays a significant role in an individual's predisposition to obesity," said the genome institute's Dr. Eric Green.

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Sen. Ted Cruz (R-Texas) joined the "Glenn Beck Radio Program" to explain how mail-in ballots are typically disqualified during recounts at a far higher rate than in-person, Election Day ballots, and why this is "good news" for President Donald Trump's legal battle over the election.

"One of the things that gives the greatest cause for optimism is, this election ... there's a pretty marked disparity in terms of how the votes were distributed. On Election Day, with in-person voting, Donald Trump won a significant majority of the votes cast on in-person voting on Election Day. Of mail-in voting, Joe Biden won a significant majority of the votes cast early on mail-in voting," Cruz explained.

"Now, here's the good news: If you look historically to recounts, if you look historically to election litigation, the votes cast in person on Election Day tend to stand. It's sort of hard to screw that up. Those votes are generally legal, and they're not set aside. Mail-in votes historically have a much higher rate of rejection … when they're examined, there are a whole series of legal requirements that vary state by state, but mail-in votes consistently have a higher rate of rejection, which suggests that as these votes begin being examined and subjected to scrutiny, that you're going to see Joe Biden's vote tallies go down. That's a good thing," he added. "The challenge is, for President Trump to prevail, he's got to run the table. He's got to win, not just in one state but in several states. That makes it a lot harder to prevail in the litigation. I hope that he does so, but it is a real challenge and we shouldn't try to convince ourselves otherwise."

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Fox News senior meteorologist Janice Dean is perhaps even more disgusted with New York Gov. Andrew Cuomo (D) for his coronavirus response than BlazeTV's Stu Burguiere (read what Stu has to say on the subject here), and for a good reason.

She lost both of her in-laws to COVID-19 in New York's nursing homes after Gov. Cuomo's infamous nursing home mandate, which Cuomo has since had scrubbed from the state's website and blamed everyone from the New York Post to nursing care workers to (every leftist's favorite scapegoat) President Donald Trump.

Janice joined Glenn and Stu on the "Glenn Beck Radio Program" Tuesday to ask why mainstream media is not holding Gov. Cuomo — who recently published a book about his leadership during the COVID-19 pandemic — accountable?

"I'm vocal because I have not seen the mainstream media ask these questions or demand accountability of their leaders. [Cuomo] really has been ruling with an iron fist, and every time he does get asked a question, he blames everybody else except the person that signed that order," Janice said.

"In my mind, he's profiting off the over 30 thousand New Yorkers, including my in-laws, that died by publishing a book on 'leadership' of New York," she added. "His order has helped kill thousands of relatives of New York state. And this is not political, Glenn. This is not about Republican or Democrat. My in-laws were registered Democrats. This is not about politics. This is about accountability for something that went wrong, and it's because of your [Cuomo's] leadership that we're put into this situation."

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As America grows divided and afraid to disagree with the Democrats' woke plan for America, Megyn Kelly is ready to fight back for the truth. For nearly two decades, she navigated the volatile and broken world of the media. But as America leans on independent voices more than ever, she's breaking new ground with "The Megyn Kelly Show."

She joined the latest Glenn Beck Podcast to break down what's coming next after the election: Black Lives Matter is mainstream, leftists are making lists of Trump supporters, and the Hunter Biden scandal is on the back burner.

Megyn and Glenn reminisce about their cable news days (including her infamous run-in with then-presidential candidate Donald Trump) and to look into the chaotic and shady world of journalism and the growing entitlement it's bred. For example, many conservatives have been shocked by how Fox News handled the election.

Megyn defended Fox News, saying she believes Fox News' mission "is a good one," but also didn't hold back on hosts like Neil Cavuto, who cut off a White House briefing to fact check it — something she never would have done, even while covering President Obama.

Megyn also shared this insightful takeaway from her time at NBC: "Jane Fonda was an ass."

Watch the full podcast here:

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Glenn Beck has had enough of exposing scandal after scandal, just to have everyone look the other way: Benghazi, Hillary Clinton's emails, Joe and Hunter Biden's dealings in Ukraine and China … the list goes on, but no consequences are paid. Now, the media have called the election for Joe Biden and insist no one can question it. But for many of the more than 71 million people who voted for President Trump, our search for the truth isn't over yet.

On his Wednesday night special this week, Glenn called out the left's long list of alleged corruption that has gone unchecked and stressed that Donald Trump's legal team must be allowed to go through the process of investigating the multiple allegations of election fraud to ensure our voting systems are fair.

"I don't know about you, but I'm tired. I am worn out. I am fed up!" Glenn said during his opening monologue. "I've had enough. I am tired of exposing corruption, doing our homework, even going overseas and having documents translated to make sure they're exactly right, [and] presenting the evidence ... except, once we expose it, nothing happens. Nobody goes to jail. Nobody pays for a damn thing any more!"

Watch the short video clip from the full show below:


Because the content of this show is sure to set off the Big Tech censors, the full episode is only be available on BlazeTV. The election and its aftermath are the most important stories in America, so we're offering our most timely discount ever: $30 off a one-year subscription to BlazeTV with code "GLENN."