Study finds six new gene mutations linked to obesity

WASHINGTON (Reuters) - Researchers have identified six new gene mutations linked to obesity and said on Sunday they point to ways the brain and nervous system control eating and metabolism.

"Today's findings are a major step forward in understanding how the human body regulates weight," Dr. Alan Guttmacher, Acting director of the National Human Genome Research Institute, said in a statement.

"This study essentially doubles in one fell swoop the number of known and replicated genetic factors contributing to obesity as a public health problem," added Dr. Kari Stefansson, Chief Executive Officer of deCODE Genetics of Iceland and one of the researchers.

The international team analyzed 300,000 one-letter mutations in the genetic code known as single nucleotide polymorohisms or SNPs in more than 30,000 people from Iceland, the Netherlands and the United States.

They cross-checked their findings in 40,000 people from Denmark and the United states.

They found variations in six genes -- TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 -- were strongly associated with a height-to-weight ratio known as body mass index or BMI.

"Today's findings are a major step forward in understanding how the human body regulates weight," said Guttmacher, whose institute, one of the National Institutes of Health, helped fund and conduct the study.

"One of the most notable aspects of these discoveries is that most of these new risk factors are near genes that regulate processes in the brain," added Stefansson, whose company hopes to sell genetic tests based on such discoveries.

"This suggests that as we work to develop better means of combating obesity, including using these discoveries as the first step in developing new drugs, we need to focus on the regulation of appetite at least as much as on the metabolic factors of how the body uses and stores energy," Stefansson said.

"These new variants may point to valuable new drug targets," he added.

Nearly a third of U.S. adults are considered obese with a BMI of 30 or more. Obesity is associated with more than 100,000 deaths each year in the U.S. population and trends are similar in many other countries.

"We know that environmental factors, such as diet, play a role in obesity, but this research further provides evidence that genetic variation plays a significant role in an individual's predisposition to obesity," said the genome institute's Dr. Eric Green.

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Taiwan's Foreign Minister Joseph Wu is now warning that his nation is preparing for war with China after Beijing flew a record number of warplanes over Taiwanese territory. Wu reached out to another country for help, but it wasn't the United States.

In a video, Wu urged Australia to help prepare for a possible invasion, but gave the U.S. no mention.

"The defense of Taiwan is in our own hands, and we are absolutely committed to that. And if China is going to launch a war against Taiwan, we will fight until the end. And that is our commitment. And, of course, during this period of time, we would like to exchange with other countries for security cooperation," Wu said on ABC News In-depth's China Tonight program. "We would like to engage in security or intelligence exchanges with other like-minded partners, Australia included, so that Taiwan is better prepared to deal with the war situation. And so far, our relations with Australia is very good. And that is what we appreciate it for."

On "The Glenn Beck Program," Glenn, Pat Gray, and Stu Burguiere discussed whether or not America would do anything during such a conflict — because it sure seems like President Joe Biden is more focused on working with China to fight climate change. Plus, why did China just cut off all cryptocurrency?

Watch the video clip below to catch the conversation:

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On "Glenn TV" tonight, Glenn Beck heads to the chalkboard to reveal how the fundamental transformation of America has already begun by turning the Declaration of Independence upside down.

If Donald Trump was a dictator, then what do we call President Biden? In Biden's first nine months in office, he has already issued 64 executive orders – that's more than Trump, Obama, W. Bush, Clinton, Bush, and Reagan each issued in their entire first years in office.

You never hear the Left talk about the Declaration of Independence, the Constitution, or the Bill of Rights any more, unless it's to "reimagine" the Constitution or slap a "harmful content" warning on our founding documents. Seriously. The National Archives said while its website label wasn't targeting the Constitution specifically, "some of the materials presented here may reflect outdated, biased, offensive, and possibly violent views and opinions." The Left finds basic, guaranteed rights so offensive they now spend all of their time on workarounds to deal with America's annoying founding documents.

Watch the full episode of "Glenn TV" below to see Glenn outline the aggressive unconstitutional abuses "King Biden" is jamming down our throats and teaches Americans how we can defend against presidential tyranny.

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On the "Glenn Beck Radio Program," Glenn explained why he wouldn't be surprised to see our supply chain collapse and empty shelves in America in the near future. Shortages are already wrecking our economy, China (where many of our goods are still made) is facing an energy shortage, and the Biden administration sure seems to be doing everything it can to make things worse.

Glenn noted a serious warning from American CEO Mike Beckham: "There's a major storm brewing in the supply chain," Beckham wrote on Twitter.

Thanks to China's centrally planned system, electricity shortages are causing huge delays in product manufacturing. In fact, some items are facing a 33 percent cut in production. "It could dramatically impact every [American's] life next year. But almost no one knows about it yet," Beckham warned.

Glenn went on to explain exactly what this means for you — and what you can do to prepare.

Watch the video clip below to hear Glenn break it down:


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Every decision made by President Joe Biden has ended in "disaster," Bill O'Reilly told Glenn Beck.

O'Reilly joined the radio program to explain why he thinks there's only one "mechanism" Americans can use stop the Biden administration's mess.

"Give me one thing that [Biden] has done, just one, that's improved this nation. Everything that he has been involved with is a disaster. Everything from the COVID mandates, to the energy policies, to the economic policies, to the inflation, to Afghanistan, to the collapsing southern border, to the social woke business, to the denial of due process. Right across-the-board, there isn't anything this man has done, or stood for, that's improved America," O'Reilly said.

"But there is no mechanism to do anything about it until a year from this November: the midterm elections. That's the only mechanism that we have, under the Constitution. We elected this guy and he's there for four years. You neutralize him next November [2022], with the Republicans taking back the House and Senate, then he's done. [He] can't do anymore damage because you've got him in a hole. And he's not going to be proactive with executive orders. He's just going to stay there in his jammies for two more years. OK? So that's the only mechanism."

O'Reilly also tore into the corporate media for using its power to defend Gen. Mark Milley after news of his China calls broke. Is there any deterrence in American society anymore to keep our leaders and media in check?

"What does this say to the United States of America when you have two of the most powerful information agencies in the world — NBC, Comcast, and AT&T, CNN — actively deceiving you?" O'Reilly said. "They know what they're doing. And yet there is absolutely no way for anyone to hold them accountable other than not watching them, which has, of course, happened. You know they have no audience. But just the corruption level of the information flow to the American people is at an all-time high. We have never had a worse media in the history of this republic."

Watch the clip below to hear O'Reilly break it all down:

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